Suter Science Seminar - S100A1 and Heart Disease: From Molecular Characterization to Clinical Trials

Where Science Center, 104

Duration 1 hour

S100A1 and Heart Disease: From Molecular Characterization to Clinical Trials by Nathan Wright, PhD

S100A1 is a small, dimeric EF-hand containing protein that undergoes a large conformational change in the presence of calcium. This conformational change reveals a previously-hidden deep hydrophobic pocket, which allows S100A1 to bind to target proteins and influence their function. S100A1, highly expressed in muscle and cardiac cells, tightly binds to the calcium release channels in these cells and causes an increase in transient calcium release, leading to more vigorous muscle contraction. These findings have helped pave the way for S100A1 to be tested in phase I clinical trials as a treatment for cardiomyopathy.

Dr. Nathan Wright received a BS in biology from Haverford College in 2000, an MS in cellular and molecular biology from the University of Pennsylvania in 2002, and a PhD in biochemistry from the University of Maryland, Baltimore in 2008. After completing a postdoctoral fellowship at Johns Hopkins University, he joined the faculty in the department of Chemistry and Biochemistry at James Madison University as an assistant professor in 2011. He used to enjoy running on the track team and singing in an a cappella group, but these days enjoys running after toddlers and singing lullabies.

Intended Audience General Public

Tags ACAD, SCIENCE, SEMINAR, Intellectual Life

Contact Information

Name Science Center

Phone # 540.432.4400


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